abstract：:In the original publication of the article, the sentence in "Result" section have been incorrectly published as: "Three lines of tPA Tg rats were generated and analyzed by Southern blotting to confirm the presence of the transgene in genomic DNA. When rat DNA was digested with EcoRI and hybridized to the tPA probe des...

journal_title：Journal of thrombosis and thrombolysis

authors： Ito Y,Noguchi K,Morishima Y,Yamaguchi K

更新日期：2018-01-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common complication of hematologic malignancies. Prolonged periods of thrombocytopenia are experienced universally by patients undergoing treatment for these diseases, yet data to guide management of anticoagulation in this setting are lacking. To obtain data on the management and out...

journal_title：Journal of thrombosis and thrombolysis

authors： Samuelson Bannow BT,Walter RB,Gernsheimer TB,Garcia DA

更新日期：2017-11-01 00:00:00

abstract：:In vascular access practices, the internal vessel size is considered important, and a catheter to vessel ratio (CVR) is recommended to assist clinicians in selecting the most appropriate-sized device for the vessel. In 2016, new practice recommendations stated that the CVR can increase from 33 to 45% of the vessels di...

journal_title：Journal of thrombosis and thrombolysis

authors： Spencer TR,Mahoney KJ

更新日期：2017-11-01 00:00:00

abstract：:Thrombophilia, commonly manifested as venous thromboembolism (VTE), is a worldwide concern but little is known on its genetic epidemiology in many parts of the globe particularly in the developing countries. Here we employed TaqMan genotyping and pyrosequencing to evaluate the prevalence of known common nucleotide pol...

journal_title：Journal of thrombosis and thrombolysis

authors： Abdi AA,Osman A

更新日期：2017-11-01 00:00:00

abstract：:The risk benefit decision in providing anticoagulation for patients with brain metastases is amongst the most difficult decisions faced by clinicians. The purpose of our study was to evaluate both the risk of intracerebral hemorrhage (ICH) associated with anticoagulation therapy and the effect of anticoagulation on su...

journal_title：Journal of thrombosis and thrombolysis

authors： Hunter BD,Minichiello T,Bent S

更新日期：2017-10-01 00:00:00

abstract：:Medicinal plants have been used for treatment of human ailments since ancient times. Objective of this study is to document the effect of herbal drugs on anticoagulant therapy. The material for this review was taken mostly from PubMed and the Cochrane database of systematic reviews. Some other relevant references were...

journal_title：Journal of thrombosis and thrombolysis

authors： Akram M,Rashid A

更新日期：2017-10-01 00:00:00

abstract：:The contribution of prothrombotic genetic risk factors in the pathogenesis of premature acute myocardial infarction (MI) is controversial. We examined the prevalence of prothrombotic polymorphisms (G1691A of factor V gene [FV Leiden] and G20210A of prothrombin [FII] gene), deficiencies of natural anticoagulants (prote...

journal_title：Journal of thrombosis and thrombolysis

authors： Rallidis LS,Gialeraki A,Tsirebolos G,Tsalavoutas S,Rallidi M,Iliodromitis E

更新日期：2017-08-01 00:00:00

abstract：:High central aortic pulse pressure (CPP) and thrombin-induced platelet-fibrin clot strength (TIP-FCS) have been associated with ischemic outcomes in patients with coronary artery disease in separate studies. But, the ischemic risk associated with these factors has never been analyzed in a single study and their interr...

journal_title：Journal of thrombosis and thrombolysis

authors： Chen G,Bliden KP,Chaudhary R,Liu F,Kaza H,Navarese EP,Tantry US,Gurbel PA

更新日期：2017-08-01 00:00:00

abstract：:To identify the pathogenesis of a Chinese woman diagnosed with dysfibrinogenemia. A patient from Nanjing presented with a low plasma concentration of fibrinogen and a normal level of antigen of fibrinogen. This abnormality was also detected in her son. To detect whether the genetic mutation was responsible for the dys...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhou N,Xu P,Zhou M,Xu Y,Li P,Chen B,Ouyang J,Zhou R

更新日期：2017-07-01 00:00:00

abstract：:Recent gene knockout studies on mice have shown the role of toll-like receptor 9 (TLR9) in resolution of venous thromboembolism (VTE) through sterile inflammation. However, the role of a putative functional TLR9 polymorphism (rs5743836) in risk assessment of VTE recurrence remains unknown. The aim of our study was to ...

journal_title：Journal of thrombosis and thrombolysis

authors： Ahmad A,Sundquist K,Zöller B,Svensson PJ,Sundquist J,Memon AA

更新日期：2017-07-01 00:00:00

abstract：:A cardiocerebral ischemic attack (CCI) or a concurrent acute ischemic stroke (AIS) and myocardial infarction (AMI) is a severe event with no clear recommendations for ideal management because of the rarity of the scenario. The narrow time window for treatment and complexity of the treatment decision puts immense press...

journal_title：Journal of thrombosis and thrombolysis

authors： Yeo LLL,Andersson T,Yee KW,Tan BYQ,Paliwal P,Gopinathan A,Nadarajah M,Ting E,Teoh HL,Cherian R,Lundström E,Tay ELW,Sharma VK

更新日期：2017-07-01 00:00:00

abstract：:Non vitamin K oral anticoagulants (NOACs) do not require regular monitoring but information about their pharmacodynamic effect may be importantin situations like trauma, stroke oremergent surgery. Currently, no standardized point-of-care test is available to evaluate the anticoagulant effects of NOACs. We evaluated th...

journal_title：Journal of thrombosis and thrombolysis

authors： Bliden KP,Chaudhary R,Mohammed N,Muresan AA,Lopez-Espina CG,Cohen E,Raviv G,Doubleday M,Zaman F,Mathew B,Tantry US,Gurbel PA

更新日期：2017-05-01 00:00:00

abstract：:Many hospitals have implemented warfarin dosing nomograms to improve patient safety. To our knowledge, no study has assessed the impact inpatient warfarin initiation has in both medical and surgical patients, on safety outcomes post discharge. To evaluate the impact of a suggested institutional nomogram for the initia...

journal_title：Journal of thrombosis and thrombolysis

authors： Chamoun N,Macías CG,Donovan JL,Klugman R,Gore J,Salameh P,Tran MT

更新日期：2017-05-01 00:00:00

abstract：:Bleeding refers to the most important complication during anticoagulation therapy in patients with pulmonary embolism (PE). However, the incidence and risk factors of bleeding in Chinese population with anticoagulant therapy remains unknown. Although diabetes mellitus (DM) has been demonstrated to increase the risk of...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang Z,Zhai Z,Yang Y,Wan J,Xie W,Zhu J,Shen YH,Wang C

更新日期：2017-05-01 00:00:00

abstract：:In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There ...

journal_title：Journal of thrombosis and thrombolysis

authors： Berndt R,Rusch R,Hummitzsch L,Lutz M,Heß K,Huenges K,Panholzer B,Otte C,Haneya A,Lutter G,Schlaefer A,Cremer J,Groß J

更新日期：2017-04-01 00:00:00

abstract：:Oxidative stress-induced platelet apoptosis is one among the many causes for the development and progression of many disorders like cardiovascular diseases, arthritis, Alzheimer's disease and many chronic inflammatory responses. Many studies have demonstrated the less optimal effect of N-acetyl cysteine (NAC) in oxida...

journal_title：Journal of thrombosis and thrombolysis

authors： Paul M,Thushara RM,Jagadish S,Zakai UI,West R,Kemparaju K,Girish KS

更新日期：2017-02-01 00:00:00

abstract：:Cirrhosis is a consequence of prolonged liver injury and is characterised by extensive tissue fibrosis: the deposition of collagen-rich extracellular matrix. The haemostatic balance is disordered in cirrhosis and coagulation activation appears to promote fibrosis. In spite of recent studies demonstrating a role for an...

journal_title：Journal of thrombosis and thrombolysis

authors： Egan K,Dillon A,Dunne E,Kevane B,Galvin Z,Maguire P,Kenny D,Stewart S,Ainle FN

更新日期：2017-01-01 00:00:00

abstract：:Plasminogen plays an important role in fibrinolysis as well as wound healing, cell migration, tissue modeling and angiogenesis. Congenital plasminogen deficiency is a rare autosomal recessive disorder that leads to the development of thick, wood-like pseudomembranes on mucosal surfaces, mostly seen in conjunctivas nam...

journal_title：Journal of thrombosis and thrombolysis

authors： Celkan T

更新日期：2017-01-01 00:00:00

abstract：:Direct oral anticoagulants have been shown safe and effective in the treatment of pulmonary emboli and deep vein thrombi. Their role in the treatment of patients with hypercoagulability is uncertain. We designed a retrospective exploratory analysis of all patients with definite heparin induced thrombocytopenia (HIT) a...

journal_title：Journal of thrombosis and thrombolysis

authors： Kunk PR,Brown J,McShane M,Palkimas S,Gail Macik B

更新日期：2017-01-01 00:00:00

abstract：:Intravenous (IV) thrombolysis is the treatment in ischemic stroke, but only the minority of patients receive this medication. The primary objective of this study was to explore the reasons associated with the decision not to offer IV thrombolysis to stroke patients admitted to the Stroke Unit (SU). We conducted a retr...

journal_title：Journal of thrombosis and thrombolysis

authors： Cappellari M,Bosco M,Forlivesi S,Tomelleri G,Micheletti N,Carletti M,Bovi P

更新日期：2016-11-01 00:00:00

abstract：UNLABELLED:Platelet P-selectin and activated glycoprotein IIb-IIIa (GPIIb-IIIa) are markers of platelet activation and mediates platelet aggregation. Prasugrel (Pras) 5 mg may be used in very elderly (VE) acute coronary syndrome (ACS) patients undergoing PCI, but its effect on platelet P-selectin and activated GPIIb-II...

journal_title：Journal of thrombosis and thrombolysis

authors： Wagner H,Lood C,Borna C,Gidlöf O,Truedsson L,Brown P,Zhou C,Winters K,Jakubowski JA,Erlinge D

更新日期：2016-10-01 00:00:00

abstract：:Atrial fibrillation (AF) is a common cardiac arrhythmia. Dabigatran etixalate (DE) is one of the new oral anticoagulant drugs being used in nonvalvular AF (NVAF). There is no adequate real world data in different populations about DE. The aim of this registry was to evaluate the efficacy and safety of DE Consecutive N...

journal_title：Journal of thrombosis and thrombolysis

authors： Yavuz B,Ayturk M,Ozkan S,Ozturk M,Topaloglu C,Aksoy H,Şabanoglu C,Tanalp AC,Dal K,Ata N,Yavuz BB

更新日期：2016-10-01 00:00:00

abstract：:A 64-year-old man first developed ligneous conjunctivitis at the age of 58 years after right pulmonary resection because of suspected cancer; otherwise, he had been healthy. Since then, he began to suffer from various forms of chronic pseudomembranous mucositis. Laboratory tests demonstrated that he had 7.8 % of plasm...

journal_title：Journal of thrombosis and thrombolysis

authors： Osaki T,Souri M,Song YS,Izumi N,Law R,Ichinose A

更新日期：2016-08-01 00:00:00

abstract：:Fibrinogen depletion via catalysis by snake venom enzymes as a therapeutic strategy to prevent or treat thrombotic disorders was utilized for over four decades, with ancrod being the quintessential agent. However, ancrod eventually was found to not be of clinical utility in large scale stroke trial, resulting in the e...

journal_title：Journal of thrombosis and thrombolysis

authors： Nielsen VG

更新日期：2016-08-01 00:00:00

abstract：:Inherited afibrinogenemia and hypofibrinogenemia are rare bleeding disorders characterized by markedly reduced levels of fibrinogen in blood. Thrombotic complications in these disorders have been rarely described. We performed a multicenter retrospective study and reviewed the occurrence of thrombotic complications am...

journal_title：Journal of thrombosis and thrombolysis

authors： Rottenstreich A,Lask A,Schliamser L,Zivelin A,Seligsohn U,Kalish Y

更新日期：2016-08-01 00:00:00

abstract：:The American College of Chest Physicians (ACCP) has established guidelines for the treatment of VTE, but the generalizability to all populations is unclear. In this review we analyzed the rate of reporting and enrollment of blacks and women in clinical trials cited in the ACCP guidelines for treatment of unprovoked VT...

journal_title：Journal of thrombosis and thrombolysis

authors： Sullivan LT 2nd,Jackson LR 2nd,Thomas KL

更新日期：2016-08-01 00:00:00

abstract：:Specific therapy of acute spinal ischemia is not established. We report the first case of an MRI-verified cervical spinal ischemia treated by thrombolysis and review the literature. A 72-year old woman with right-sided motor hemiparesis and trunk ataxia was treated by intravenous thrombolysis with full recovery. Three...

journal_title：Journal of thrombosis and thrombolysis

authors： Etgen T,Höcherl C

更新日期：2016-07-01 00:00:00

abstract：:The home prothrombin time/international normalized ratio (PT/INR) self-management could be convenient for patients, enhancing treatment compliance and improving the quality of the oral anticoagulation. However, patient self-management (PSM) of oral anticoagulation may not be feasible for up to half of the patients due...

journal_title：Journal of thrombosis and thrombolysis

authors： da Silva Saraiva S,Orsi FA,Santos MP,Machado T,Montalvão S,Costa-Lima C,de Paula EV,Colella MP,Annichino-Bizzacchi J

更新日期：2016-07-01 00:00:00

abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people and cause the chronic debilitating disease schistosomiasis. While these large intravascular parasites can disturb blood flow, surprisingly they do not appear to provoke thrombus formation around them in vivo. In order to determine ...

journal_title：Journal of thrombosis and thrombolysis

authors： Da'dara AA,de Laforcade AM,Skelly PJ

更新日期：2016-05-01 00:00:00

abstract：:D-dimer levels are increased in patients with acute pulmonary embolism (PE). However, D-dimer levels are also increased in patients with community-acquired pneumonia (CAP). The aim of this prospective cohort study was to examine the incidence and clinical features of patients preliminarily diagnosed with CAP and with ...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang Y,Zhou Q,Zou Y,Song X,Xie S,Tan M,Zhang G,Wang C

更新日期：2016-05-01 00:00:00

abstract：:Throughout the world, herbal medicines are consumed by most of the patients without considering their adverse effects. Many herbal medicines/plant extracts have been reported to interact with the natural blood clotting system. In continuation to this effort, thirty medicinal plant extracts were allowed to interact wit...

journal_title：Journal of thrombosis and thrombolysis

authors： Adhyapak MS,Kachole MS

更新日期：2016-05-01 00:00:00

abstract：:Each year venous thromboembolism (VTE) causes up to 60,000 deaths in the UK, many resulting from hospital-acquired thromboses following elective surgery. National Institute for Health and Clinical Excellence (NICE) guidelines state that all elective surgical patients should receive verbal and written information pre-o...

journal_title：Journal of thrombosis and thrombolysis

authors： Haymes A

更新日期：2016-04-01 00:00:00

abstract：:Unfractionated heparin (UFH) plasma protein binding and elimination might be impaired in patients with chronic kidney disease (CKD-defined as creatinine clearance <60 ml/min). It is currently unknown at which UFH bolus dose persistent prolongation of activated partial thromboplastin time (aPTT) occurs in ST-segment el...

journal_title：Journal of thrombosis and thrombolysis

authors： Kikkert WJ,van Brussel PM,Damman P,Claessen BE,van Straalen JP,Vis MM,Baan J Jr,Koch KT,Peters RJ,de Winter RJ,Piek JJ,Tijssen JG,Henriques JP

更新日期：2016-04-01 00:00:00

abstract：:Anticoagulation treatment is effective in preventing both death and recurrence in patients with venous thromboembolism (VTE), but at the same time confers a substantial risk of bleeding complications. The aim of this study was to examine the rate of and predictors for bleeding complications in VTE patients on warfarin...

journal_title：Journal of thrombosis and thrombolysis

authors： Sandén P,Renlund H,Svensson PJ,Själander A

更新日期：2016-02-01 00:00:00

abstract：:Over the past several years, non-vitamin K oral anticoagulants (NOACs) have been introduced into clinical practice for the treatment of venous thromboembolism and prevention of stroke in patients with nonvalvular atrial fibrillation. Clinical trials have shown these agents to have similar or less risk of major bleedin...

journal_title：Journal of thrombosis and thrombolysis

authors： Washam JB,Piccini JP

更新日期：2016-02-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a highly prevalent complication of malignancy with emerging changes in incidence, diagnosis and treatment paradigms. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance based on existing guidelines and consensus expert opinion where guidelines are lacking...

journal_title：Journal of thrombosis and thrombolysis

authors： Khorana AA,Carrier M,Garcia DA,Lee AY

更新日期：2016-01-01 00:00:00

abstract：:Patients with mechanical heart valves (MHV) undergoing invasive procedures often receive periprocedural bridging with low-molecular-weight heparin (LMWH). The bridging strategies used in real-life and the predictors for bleeding and thrombosis are not well studied. We retrospectively assessed patients with MHV that un...

journal_title：Journal of thrombosis and thrombolysis

authors： Schulman JM,Majeed A,Mattsson E,Schulman S,Holmström M,Ågren A

更新日期：2015-11-01 00:00:00

abstract：:Aspirin has been in use for prevention and management of cardiovascular diseases for several decades. Clinical and epidemiological literature suggests that while net benefits of aspirin in primary prevention of CVDs are less clear, the benefits of aspirin in acute scenarios and secondary prevention settings are well e...

journal_title：Journal of thrombosis and thrombolysis

authors： Ganjehei L,Becker RC

更新日期：2015-11-01 00:00:00

abstract：:Amlodipine, commonly used for relief of ischemic symptoms in coronary artery disease (CAD), may affect clopidogrel-induced antiplatelet effects. It remains unknown if ranolazine, an antianginal drug that constitutes a pharmacologic alternative to calcium channel blockade, interferes with clopidogrel-induced antiplatel...

journal_title：Journal of thrombosis and thrombolysis

authors： Pelliccia F,Greco C,Gaudio C,Rosano G,Vitale C,Marazzi G,Rollini F,Angiolillo DJ

更新日期：2015-10-01 00:00:00

abstract：:Data comparing the patient characteristics, management and outcomes for dabigatran versus warfarin major bleeding in the practice setting are limited. We performed a retrospective single health system study of atrial fibrillation patients with dabigatran or warfarin major bleeding from October 2010 through September 2...

journal_title：Journal of thrombosis and thrombolysis

authors： Smythe MA,Forman MJ,Bertran EA,Hoffman JL,Priziola JL,Koerber JM

更新日期：2015-10-01 00:00:00